Related Experiment Video
Updated: Mar 21, 2026
Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
The SCCAI and Mayo Endoscopic Severity Scores Are Positively Correlated with QIDS-SR16 Depression Scores in Patients
Ziqi Yang1, Shu Pang1, Chunyan Jiang1
1Department of General Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.
Background:
Ulcerative colitis (UC) is often accompanied by depressive symptoms, yet the association between disease activity and depression remains insufficiently characterized.
Objective:
To evaluate the correlations between SCCAI scores, Mayo endoscopic severity scores, and QIDS-SR16 depression scores in patients with UC.
Methods:
This cross-sectional study included 106 hospitalized UC patients from January 2023 to December 2024. Disease activity was assessed using the Simple Clinical Colitis Activity Index (SCCAI), and endoscopic severity was assessed with the Mayo score in a subsample (n = 54). Depressive symptoms were evaluated using QIDS-SR16. Multivariable linear regression and restricted cubic spline models were applied to examine linear and nonlinear associations.
Results:
A 1-point increase in SCCAI score was associated with a 0.41-point increase in QIDS-SR16 score (β = 0.41, 95% CI: 0.19-0.63, P < 0.001). A 1-point increase in the Mayo score corresponded to a 1.07-point increase in QIDS-SR16 (β = 1.07, 95% CI: 0.24-1.90, P = 0.015). Restricted cubic spline analysis revealed a nonlinear association between SCCAI and QIDS-SR16, with greater sensitivity of depressive symptoms at lower SCCAI levels.
Conclusion:
In this cross-sectional real-world study, both clinical disease activity (SCCAI) and endoscopic severity (Mayo score) were independently and positively correlated with depressive symptom burden in UC patients. These findings support incorporating routine depression screening into UC clinical management to facilitate timely detection and intervention.
More Related Videos
Related Concept Videos
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:17Assessment of the Gastrointestinal System I: Subjective Data
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
01:29Drugs for Treatment of Ulcerative Colitis in IBD