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Abnormal Proliferation02:23

Abnormal Proliferation

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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Related Experiment Video

Updated: Mar 21, 2026

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

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Pediatric Solid Pseudopapillary Neoplasm With Aberrant CD31 Expression: A Potential Diagnostic Pitfall.

Jameera Nazer1, Archana G Vallonthaiel1, Jyotsna Yesodharan1

  • 1Pathology, Amrita Institute of Medical Sciences, Kochi, IND.

Cureus
|March 20, 2026
PubMed
Summary

Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor. Aberrant CD31 expression in a pediatric case mimicked vascular neoplasm, highlighting diagnostic challenges in biopsies.

Area of Science:

  • Oncology
  • Pathology
  • Pediatric Surgery

Background:

Keywords:
biopsydiagnostic errorsimmunohistochemistry stainingpancreatic neoplasmssolid pseudopapillary neoplasm of the pancreas

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  • Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor with low malignant potential, typically affecting young women.
  • Pediatric SPN is exceptionally rare, posing diagnostic challenges due to potential unusual histomorphology and immunohistochemical findings.
  • Diagnostic difficulties can arise from extensive necrosis or aberrant marker expression in biopsy specimens.