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Published on: July 5, 2022
Intravitreal Anti-vascular Endothelial Growth Factor in Retinopathy of Prematurity: A Bibliometric Analysis
Onkar H Pirdankar1, Amit S Nene2, Renu Thakur3
1Departments of Optometry, Isha Netralaya, Kalyan, Maharashtra, India.
Insights
This bibliometric analysis reveals research trends in using anti-vascular endothelial growth factor (VEGF) for retinopathy of prematurity (ROP). It identifies leading countries, authors, and journals in this evolving field.
Area of Science:
- Ophthalmology
- Neonatology
- Bibliometrics
Background:
- Retinopathy of prematurity (ROP) is a primary cause of blindness in premature infants.
- Intravitreal anti-vascular endothelial growth factor (VEGF) therapies are increasingly utilized for ROP management.
- Understanding research trends is crucial for advancing ROP treatment strategies.
Purpose of the Study:
- To conduct a bibliometric analysis of research on intravitreal anti-VEGF agents in retinopathy of prematurity.
- To identify publication trends, productive countries, influential researchers, and key journals in the field.
- To map the intellectual structure and research landscape of anti-VEGF therapy for ROP.
Main Methods:
- A comprehensive search of the Scopus database was performed using keywords related to anti-VEGF and ROP.
- Original research and review articles published in English were included.
- VOSviewer software was used for data visualization and analysis, including publication trends, country productivity, author output, citation analysis, journal impact, and keyword co-occurrence.
Main Results:
- A total of 329 studies (270 original, 59 review) were analyzed, with a publication peak in 2022.
- The United States, China, Turkey, India, and Taiwan were the most productive countries.
- Wei-Chi Wu and Chi-Chun Lai were the most prolific authors, and Falavarjani et al.'s article received the most citations (737).
- Keywords 'retinopathy of prematurity' and 'human' were most frequent.
- The journal *Retina* published the most articles and received the most citations.
Conclusions:
- The use of anti-VEGF in ROP is a dynamic research area.
- This bibliometric analysis provides insights into research trends, key contributors, and influential publications.
- The findings can guide future researchers in conducting literature reviews and identifying research gaps in anti-VEGF therapy for ROP.
Abstract:
Retinopathy of prematurity (ROP) is one of the leading cause of blindness in premature infants. A bibliometric analysis on intravitreal anti-vascular endothelial growth factor (VEGF) in ROP was conducted. A comprehensive search of the article on the Scopus database was conducted with the terms related to "anti-vascular endothelial growth factor and retinopathy of prematurity." Only original research and review articles published in the English language were considered. VOSviewer version 1.6.20 was used for the visualization and analysis of the data. Publication trend, productive countries, researchers' details, commonly cited documents, source and influential journals, and keyword occurrence were analyzed. A total of 329 studies were considered, of which 270 were original articles and 59 were review articles. The highest numbers of publications were seen in the year 2022. The United States, China, Turkey, India, and Taiwan were the top 5 countries that published research on the use of anti-VEGF in ROP. The most documents were published by Wei-Chi Wu (22) and Chi-Chun Lai (14), and Falavarjani et al's article had the most citations (737). A total of 2,504 keywords were identified. All keyword analysis revealed the occurrence of "retinopathy of prematurity" and "human" as a keyword was 290 and 286 times, respectively. Most articles and citations were found in Retina. The use of anti-VEGF in ROP is constantly evolving and bibliometric analysis highlights a research trend and influential authors and journals that have published significant work on it. This article can serve as a guide to conduct a literature review for future researchers.
