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Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

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Related Experiment Video

Updated: Mar 21, 2026

Establishment and Genetic Manipulation of Murine Hepatocyte Organoids

Establishment and Genetic Manipulation of Murine Hepatocyte Organoids

Published on: February 12, 2022

[Liver organoids: from promise to functional complexity].

Eléanor Luce¹, Jean-Charles Duclos-Vallée¹

¹Inserm, Université Paris-Saclay, UMRS1193, Villejuif, France.

Medecine Sciences : M/S

|March 20, 2026

Summary

Liver organoids are advancing rapidly with new complexity and functionality. These engineered tissues show promise for disease modeling, drug testing, and personalized medicine applications.

Area of Science:

Regenerative Medicine
Tissue Engineering
Stem Cell Biology

Background:

Stem cell biology and tissue engineering have significantly advanced liver organoid development.
Modern liver organoids exhibit increased maturity and complexity.

Purpose of the Study:

To highlight recent advancements in liver organoid technology.
To underscore the expanding applications of these organoids in biomedical research and medicine.

Main Methods:

Incorporation of functional canalicular networks.
Development of metabolic gradients within organoids.
Co-culture systems involving cholangiocytes, stellate cells, and macrophages.
Integration of vascularization, bioprinting, and microfluidics technologies.

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Generation of Functional Endodermal Hepatic Organoids

Generation of Functional Endodermal Hepatic Organoids

Published on: May 2, 2025

Rat Liver Perfusion and Primary Hepatocytes Isolation: An Old Procedure Crucial for Cutting-Edge 3D Organoids Culture

Rat Liver Perfusion and Primary Hepatocytes Isolation: An Old Procedure Crucial for Cutting-Edge 3D Organoids Culture

Published on: November 22, 2024

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Last Updated: Mar 21, 2026

Establishment and Genetic Manipulation of Murine Hepatocyte Organoids

Establishment and Genetic Manipulation of Murine Hepatocyte Organoids

Published on: February 12, 2022

Generation of Functional Endodermal Hepatic Organoids

Generation of Functional Endodermal Hepatic Organoids

Published on: May 2, 2025

Rat Liver Perfusion and Primary Hepatocytes Isolation: An Old Procedure Crucial for Cutting-Edge 3D Organoids Culture

Rat Liver Perfusion and Primary Hepatocytes Isolation: An Old Procedure Crucial for Cutting-Edge 3D Organoids Culture

Published on: November 22, 2024

Main Results:

Enhanced stability and functionality of liver organoids.
Improved models for studying liver diseases.
More accurate platforms for pharmacological testing.
Potential for personalized medicine approaches.

Conclusions:

Liver organoids are becoming increasingly sophisticated tools.
These advancements are broadening their utility for various biomedical applications, including therapeutics.