Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

24.6K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.6K
MicroRNAs01:22

MicroRNAs

4.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

12.0K
12.0K
RNA Interference01:23

RNA Interference

28.5K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.5K
RNA Interference01:23

RNA Interference

7.8K
7.8K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.1K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lin28/let-7 axis in breast cancer.

Molecular biology reports·2025
Same author

MicroRNAs in diabetes mellitus.

Journal of diabetes and metabolic disorders·2025
Same author

Molecular markers predicting the progression and prognosis of human papillomavirus-induced cervical lesions to cervical cancer.

Journal of cancer research and clinical oncology·2023
Same author

Nonpharmaceutical interventions reduce the incidence and mortality of COVID-19: A study based on the survey from the International COVID-19 Research Network (ICRN).

Journal of medical virology·2022
Same author

Biology of tomato flu.

New microbes and new infections·2022
Same author

Monkeypox: epidemiology, mode of transmission, clinical features, genetic clades and molecular properties.

European review for medical and pharmacological sciences·2022

Related Experiment Video

Updated: Mar 22, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

3.0K

microRNA-155: a versatile noncoding RNA.

P Shaik Syed Ali1, Md Parwez Ahmad2, K M Huria Parveen2

  • 1School of Medicine, The Maldives National University, Male', Maldives. shaik.syed@mnu.edu.mv.

Molecular Biology Reports
|March 20, 2026
PubMed
Summary

MicroRNAs (miRNAs) regulate gene expression. This review focuses on miR-155, highlighting its critical roles in metabolism, immunity, and diseases like cancer and autoimmune conditions.

Keywords:
Autoimmune diseaseCancerMetabolic disordersmiRNA155microRNA

More Related Videos

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
09:29

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

8.0K
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

490

Related Experiment Videos

Last Updated: Mar 22, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

3.0K
A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
09:29

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

8.0K
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

490

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression post-transcriptionally.
  • Over 2,700 human miRNAs identified, but functions known for fewer than 600.
  • miR-155 is a key regulatory miRNA with diverse biological roles.

Purpose of the Study:

  • To review the physiological and pathological functions of miR-155.
  • To summarize current knowledge on miR-155's involvement in various diseases.
  • To highlight miR-155's role in gene regulation and disease pathogenesis.

Main Methods:

  • Literature review of existing studies on miR-155.
  • Analysis of research on miR-155's involvement in metabolic disorders.
  • Examination of evidence linking miR-155 to immune homeostasis and autoimmune diseases.
  • Review of studies on miR-155's role in cancer development.

Main Results:

  • Dysregulated miR-155 expression is linked to metabolic disorders (diabetes, preeclampsia).
  • miR-155 plays a role in immune homeostasis and autoimmune diseases (rheumatoid arthritis, lupus).
  • Aberrant miR-155 expression contributes to tumorigenesis by affecting tumor suppressor genes.

Conclusions:

  • miR-155 is a crucial regulator in normal physiology and disease.
  • Understanding miR-155's functions is vital for developing therapeutic strategies.
  • Further research is needed to fully elucidate miR-155's complex roles in health and disease.