Related Experiment Video
Updated: Mar 22, 2026
15:43
Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
Published on: March 17, 2014
24.1K
Bidirectional association between chronic periodontitis and bronchiectasis: A nationwide, population-based cohort
Sungmin Zo1, Min Ji Kim2, Min Gu Kang2
1Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Respiratory Medicine
|March 20, 2026
Summary
Chronic periodontitis (CP) significantly increases bronchiectasis risk. Bronchiectasis also elevates CP risk, but CP has a stronger impact on developing bronchiectasis. This study explored their bidirectional link.
Area of Science:
- Medical research
- Public health
- Epidemiology
Background:
- Investigated the link between chronic periodontitis (CP) and bronchiectasis.
- Utilized the Korean National Health Insurance Service claims database.
Purpose of the Study:
- To examine the potential bidirectional association between CP and bronchiectasis.
- To quantify the risk of developing one condition given the other.
Main Methods:
- Two cohort studies using 1:1 propensity score matching.
- Study I: CP patients (n=54,535) vs. controls; Study II: Bronchiectasis patients (n=2,804) vs. controls.
- Follow-up until diagnosis, death, or end of 2019.
Main Results:
- CP group had a 3.35-fold higher risk of developing bronchiectasis (HR 3.35; 95% CI 3.02-3.73).
- Bronchiectasis group had a 1.07-fold higher risk of developing CP (HR 1.07; 95% CI 1.01-1.15).
- Median follow-up was 11.8 years.
Conclusions:
- A significant bidirectional association exists between CP and bronchiectasis.
- CP poses a greater risk for developing bronchiectasis than vice versa.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.0K
01:24Chronic Obstructive Pulmonary Disease
3.1K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
3.1K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
4.0K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
4.0K
01:29Microbiota of the Respiratory Tract
1
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
1
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
4.1K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.1K
01:26COPD: Management Using Bronchodilators and Corticosteroids
1.1K
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
1.1K