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Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
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A Critical Four-Hour Therapeutic Window Predicts Delayed Encephalopathy Risk After Carbon Monoxide Poisoning: A
Shaokun Wang1, Yanxia Gao2, Jie Ran3
1Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
CNS Neuroscience & Therapeutics
|March 21, 2026
Summary
Timely treatment within four hours is crucial for preventing delayed encephalopathy after carbon monoxide poisoning (DEACMP). This study identifies the four-hour window as a key benchmark for optimizing emergency response and patient outcomes.
Area of Science:
- Neurology
- Toxicology
- Data Science in Medicine
Background:
- Delayed encephalopathy after carbon monoxide poisoning (DEACMP) poses a significant clinical challenge.
- The optimal therapeutic window for intervention in DEACMP is not well-defined, impacting treatment strategies.
Purpose of the Study:
- To define the temporal relationship between exposure-to-treatment interval and DEACMP risk.
- To establish a quantitative intervention threshold for DEACMP using machine learning.
Main Methods:
- A multicenter retrospective cohort study involving 1755 patients.
- Development and external validation of a gradient boosting model to predict DEACMP risk.
- Utilized Shapley Additive exPlanations (SHAP) for model interpretability.
Main Results:
- The exposure-to-treatment interval was the strongest predictor of DEACMP.
- Intervention within four hours was identified as the most critical factor in reducing risk.
- The predictive model demonstrated high performance across training, internal, and external validation sets (AUCs ranging from 0.849 to 0.944).
Conclusions:
- Treatment delay is the primary modifiable risk factor for DEACMP.
- A critical four-hour therapeutic window has been established as an evidence-based benchmark.
- Findings can inform clinical guidelines and optimize emergency response for DEACMP prevention.
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