Exploring Synergistic Anti-Psoriatic Potential of Bioactive Compounds Tyrosol and Farnesol through In-Silico and In...

Area of Science:

• Dermatology
• Pharmacology
• Biochemistry

Background:

• Psoriasis is a chronic inflammatory skin condition influenced by genetic, immune, and environmental factors.
• Understanding the molecular mechanisms underlying psoriasis is crucial for developing effective treatments.

Purpose of the Study:

• To investigate the anti-psoriatic and antioxidant properties of Tyrosol and Farnesol.
• To evaluate the binding potential of Tyrosol and Farnesol to key psoriasis-associated proteins.

Main Methods:

• Molecular docking simulations using AutoDock were employed to assess compound-protein interactions.
• In vitro antioxidant assays (DPPH, nitric oxide, hydrogen peroxide scavenging) were performed.

Main Results:

• Tyrosol and Farnesol demonstrated significant binding affinities to psoriasis-related targets like RORγt, IRAK4, and cPLA2.
• Both compounds exhibited notable antioxidant activities, with their combination showing enhanced free radical scavenging capacity.

Conclusions:

• The findings suggest Tyrosol and Farnesol can modulate key inflammatory and oxidative pathways implicated in psoriasis.
• These compounds, particularly in combination, represent potential therapeutic agents for managing psoriasis.