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Mode of Delivery and Neonatal Characteristics as Risk Factors for Childhood Asthma in Qatar: A Case-Control Study
Samah Elshaar1, Khalid Zahraldin2,3, Ahmed Adel4
1Department of Public Health, College of Health Sciences, Qatar University, Doha, Qatar.
Insights
This study found no significant association between childhood asthma and delivery mode, gestational age, or birth weight in Qatar. Findings highlight the need for region-specific research on asthma risk factors.
Area of Science:
- Pediatric Respiratory Medicine
- Epidemiology
- Public Health
Background:
- Childhood asthma prevalence is increasing globally, representing a significant public health concern.
- In Qatar, childhood asthma affects 34.6% of children, necessitating localized research.
- Existing global literature may not capture Qatar's unique socio-cultural and genetic factors influencing asthma.
Purpose of the Study:
- To investigate the association between childhood asthma and key perinatal/neonatal factors in Qatar.
- Specifically examining mode of delivery, gestational age, and birth weight in relation to asthma development.
Main Methods:
- A hospital-based case-control study conducted in Qatar (January 2020 - July 2023).
- Included 830 childhood asthma cases and 1,512 controls (ages 6-14 years).
- Analyzed Electronic Medical Records using logistic regression; managed confounders and missing data.
Main Results:
- Asthma prevalence in the study cohort was 35.4%.
- Asthma cases were more likely to be male and have a family history of asthma.
- Cesarean delivery, preterm birth, and low birth weight showed non-significant trends towards increased asthma risk.
Conclusions:
- No statistically significant associations were found between childhood asthma and the studied perinatal/neonatal factors in Qatar.
- Emphasizes the critical need to consider regional variations and context-specific factors in health outcome research.
- Highlights the importance of localized studies for understanding and addressing public health challenges like childhood asthma.
Background:
Asthma rates are rising globally, posing a significant public health challenge. In Qatar, childhood asthma affects 34.6% of children, making it a common chronic condition. The global scope of existing literature on the association between childhood asthma and perinatal and neonatal risk factors may not fully account for Qatar's distinctive socio-cultural, genetic, and healthcare aspects. Therefore, this research aims to emphasize the importance of considering regional variations in health outcomes.
Objectives:
To investigate the association between childhood asthma development and mode of delivery, gestational age, and birthweight in Qatar.
Methods:
A hospital-based case-control study was conducted in Qatar across Hamad General, Al Wakrah, and Al Khor hospitals from January 2020 to July 2023, including 830 asthma cases and 1,512 non-asthma controls aged 6-14 years. Secondary data from Electronic Medical Records were analyzed using logistic regression, with odds ratios (ORs) and adjusted odds ratios (aORs) calculated for each factor. Confounders were managed through Directed Acyclic Graphs (DAG), and multiple imputations addressed missing data.
Results:
Asthma prevalence was 35.4%. Compared to controls, asthma cases were more likely to be males (65% vs. 41%) and have a family history of asthma (31.3% vs. 1.7%). In addition, Cesarean delivery (aOR 1.15, 95% CI 0.92, 1.44), preterm birth (aOR 1.07, 95% CI 0.79), and low birth weight (aOR 1.03, 95% CI 0.61, 1.73) showed slight increases in asthma risk. However, none of these associations reached statistical significance.
Conclusion:
Despite non-significant associations, findings underscore the importance of considering regional variations and context-specific research.
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