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Related Concept Videos

Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
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Is Alzheimer's an Autoimmune Disease?

Betsi Reinoso Corrada1, Robert C Speth2

  • 1Department of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, 33328, USA.

Molecular Neurobiology
|March 23, 2026
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease may involve autoimmune processes, not just neurodegeneration. This review examines evidence for and against the autoimmune hypothesis and its therapeutic implications.

Keywords:
AstrocytesAutoantibodiesBlood-brain barrierImmunotherapyInfectious agentsMicroglia

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Area of Science:

  • Neurology
  • Immunology
  • Neuroscience

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline.
  • Key pathologies include amyloid-beta plaques and neurofibrillary tangles (hyperphosphorylated tau).
  • Emerging evidence suggests some AD variants may have autoimmune origins.

Purpose of the Study:

  • To review and evaluate evidence supporting the autoimmune hypothesis of Alzheimer's disease.
  • To examine evidence challenging the autoimmune hypothesis.
  • To explore the implications of the autoimmune hypothesis for future Alzheimer's disease therapeutics.

Main Methods:

  • Literature review of existing research.
  • Analysis of clinical evidence.
  • Evaluation of pathological findings.

Main Results:

  • Evidence supporting the autoimmune hypothesis is presented.
  • Evidence challenging the autoimmune hypothesis is discussed.
  • Potential therapeutic strategies based on the autoimmune model are explored.

Conclusions:

  • The role of autoimmune processes in Alzheimer's disease requires further investigation.
  • Understanding the autoimmune component could lead to novel therapeutic approaches.
  • This review provides a framework for future research into AD etiology and treatment.