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Related Experiment Video

Updated: Mar 24, 2026

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology
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Vascularized Cardiac Tissue Engineering: From Advances in Biofabrication to Translational Applications.

Yang Liu1,2, Zijie Zhang2, Hongbin Li3

  • 1Shanghai Heart Failure Research Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|March 23, 2026
PubMed
Summary

Engineering vascularized cardiac tissues is key for disease modeling and regenerative therapy. This review offers a framework to overcome challenges in creating functional, perfusable cardiac tissue for better human cardiac models.

Keywords:
cardiac cellscardiac organoidscardiac tissue engineeringregenerative medicinevascularized cardiac tissues

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Vascularized cardiac tissue engineering is crucial for disease modeling, drug screening, and regenerative therapies.
  • Significant advancements in stem cells, biomaterials, and biofabrication exist, yet creating functional, perfusable vasculature in engineered myocardial tissue remains a challenge.

Purpose of the Study:

  • To present a process-oriented framework for understanding vascularized cardiac tissue engineering.
  • To critically evaluate different fabrication approaches (self-assembly, mold-casting, 3D bioprinting, microfluidics) based on cardiac physiology.
  • To discuss applications and future directions for translational impact.

Main Methods:

  • Systematic analysis of cellular components, biomaterial design, and biofabrication strategies.
  • Evaluation of self-assembly, mold-casting, 3D bioprinting, and microfluidic techniques.
  • Assessment of vascular formation, perfusion stability, and myocardial function under cardiac constraints.

Main Results:

  • The review provides a framework to analyze how various engineering strategies impact vascularization and tissue function.
  • Different methods show distinct advantages and trade-offs concerning cardiac-specific physiological constraints.
  • The integrated manufacturing approach is highlighted as essential for progress.

Conclusions:

  • A unified framework is needed to advance vascularized cardiac tissue engineering.
  • Addressing challenges in vascularization is critical for developing functional human cardiac models for disease modeling and drug testing.
  • Future research should focus on integrated manufacturing strategies to accelerate translational impact.