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Jing Chen1,2,3, Qi Yin2,3, Shiheng Xu2

  • 1Department of Pulmonary and Critical Care Medicine, Yunnan Provincial Key Laboratory for Clinical Virology, Institute of Basic and Clinical Medicine, The First People's Hospital of Yunnan Province, Kunming, China.

Frontiers in Cellular and Infection Microbiology
|March 23, 2026
PubMed

Keywords:
HBV-related hepatocellular carcinomaIFN-α-induced macrophage-derived exosomePCGF3PI3K/AKT pathwaymiR-106b-3p

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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
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