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Updated: Mar 24, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Biginelli dihydropyrimidines: a tunable class of alkyl radical precursors
Shahilan Ratnam1, Shreya Unone1, Nabeel Alia1
1Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen Tammannstraße 2 37077 Göttingen Germany djansse@uni-goettingen.de.
Abstract:
Alkyl-substituted dihydropyrimidines (DHPyms), synthesised via the Biginelli reaction, are introduced as tunable alternatives to 4-alkyl Hantzsch dihydropyridines (DHPs) in radical chemistry. Leveraging the modularity of the Biginelli reaction, we systematically explored the redox properties, UV/vis absorption, and synthetic potential of DHPyms in radical-mediated transformations, identifying dimethylamino-substituted DHPym as a highly reactive, bench-stable, and easily synthesised alkyl radical precursor.
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