Related Experiment Video

Updated: Mar 24, 2026

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
12:19

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

Published on: June 27, 2015

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Role of Sodium-Glucose Transport Protein-2 Inhibitors in Renal Protection: A Narrative Review from the

Nan Ye1, Hong Cheng1

  • 1Department of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People's Republic of China.

Drug Design, Development and Therapy
|March 23, 2026
PubMed

Insights

Cardiovascular-kidney-metabolic diseases require integrated management. Sodium-glucose cotransporter-2 (SGLT-2) inhibitors offer significant renal protection and aid in managing these interconnected conditions.

Area of Science:

  • Internal Medicine
  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Cardiovascular-kidney-metabolic (CKM) diseases represent a growing global health challenge.
  • The interconnectedness of type 2 diabetes mellitus (T2D), cardiovascular disease (CVD), and chronic kidney disease (CKD) is well-documented.
  • Integrated management strategies are essential for improving patient outcomes and reducing healthcare burdens.

Purpose of the Study:

  • To review the role of renal protection within CKM syndrome.
  • To highlight the significance of sodium-glucose cotransporter-2 (SGLT-2) inhibitors in managing CKM-related conditions.
  • To discuss challenges and future directions for CKM syndrome management, particularly in China.

Main Methods:

  • This study is a narrative review.
  • It synthesizes current literature on CKM diseases, T2D, CVD, CKD, and SGLT-2 inhibitors.
  • The review focuses on renal protection strategies and management challenges.

Main Results:

  • SGLT-2 inhibitors demonstrate substantial benefits in renal protection.
  • These agents are effective in managing metabolic and cardiovascular risk factors associated with CKM syndrome.
  • The review identifies key challenges in current CKM syndrome management.

Conclusions:

  • Renal protection is a critical component of managing CKM syndrome.
  • SGLT-2 inhibitors are vital therapeutic agents for CKM syndrome.
  • Addressing management challenges and exploring future strategies are crucial for public health in China and globally.

Keywords:
cardiovascular diseasecardiovascular-kidney-metabolic syndromechronic kidney diseaseheart failuresodium-glucose cotransporter-2type 2 diabetes mellitus

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