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Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
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Related Experiment Video

Updated: Mar 24, 2026

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

Rescue Saline Washout for Popliteal Sciatic Block.

Viet Scott C Nguyen¹, Joseph E Villaluz², William Mitchell³

¹Anesthesiology, University of California, Irvine (UCI) Medical Center, Orange, USA.

|March 23, 2026

Summary

This case report demonstrates that a saline washout can reverse the effects of a popliteal sciatic nerve block. This technique offers a potential solution when local anesthetic blockade is no longer desired.

Area of Science:

Anesthesiology
Regional Anesthesia
Nerve Blocks

Background:

Rescue saline washouts are documented to reverse local anesthetic effects in interscalene and epidural blocks.
Evidence for saline washout efficacy in lower-extremity nerve blocks is limited.

Keywords:

nerve block peripheral nerve block analgesia popliteal sciatic regional anesthesiology saline lavage

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