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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Stem Cell Niche01:26

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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The Oral Microbiota01:27

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The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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Inflammation01:38

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Related Experiment Video

Updated: Mar 24, 2026

Isolation, Processing and Analysis of Murine Gingival Cells
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Inflammation dynamics modulate periodontal stem cell fate and function.

Tomaz Alves1, Carla Alvarez-Rivas2, Natcha Mahatumarat1

  • 1Department of Developmental Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, United States.

Frontiers in Immunology
|March 23, 2026
PubMed
Summary
This summary is machine-generated.

Inflammation and its resolution critically impact periodontal stem cells. Understanding these processes is key to developing new regenerative therapies for oral tissues.

Keywords:
inflammationinflammatory resolutionmesenchymal stromal cellsmucosal immunityperiodontal stem cellspro-resolving mediatorsregeneratve microenvironmentssingle-cell omics

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Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Area of Science:

  • Oral biology
  • Stem cell biology
  • Immunology

Background:

  • The periodontium contains mesenchymal stem and progenitor cells vital for tissue homeostasis and regeneration.
  • These cells' behavior is influenced by their microenvironment, especially inflammatory signals and their resolution.
  • Chronic inflammation, as seen in periodontitis, impairs stem cell function and regenerative capacity.

Purpose of the Study:

  • To investigate how inflammation and its resolution modulate periodontal stem cell behavior.
  • To explore the role of spatially organized immunoregulation in stem cell reprogramming.
  • To identify potential therapeutic strategies for oral and mucosal tissue regeneration.

Main Methods:

  • Focus on inflammatory and resolution signals affecting osteogenic programs in periodontal MSCs.
  • Comparison of periodontal MSC responses with bone marrow-derived MSCs.
  • Analysis of source-dependent differences in inflammatory susceptibility and regenerative potential.

Main Results:

  • Inflammation resolution can restore stem cell plasticity and regenerative potential.
  • Specialized pro-resolving mediators and immune cells are crucial for stem cell reprogramming.
  • Periodontal MSCs exhibit distinct responses to inflammation compared to bone marrow MSCs.

Conclusions:

  • Inflammation and resolution actively shape periodontal stem cell behavior.
  • Spatially organized immunoregulation is emerging as a key factor in stem cell function.
  • These findings offer insights for developing regenerative therapies for oral tissues.