Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

376
Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
376
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

520
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
520
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

360
Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to subjects...
360
Dose-Response Relationship: Potency and Efficacy01:22

Dose-Response Relationship: Potency and Efficacy

7.2K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
7.2K
Bioequivalence: Overview01:16

Bioequivalence: Overview

2.2K
Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
2.2K
Blind Procedures02:07

Blind Procedures

13.9K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
13.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harmonizing intervention, context, and implementation strategies with Context-Driven Co-Design (CD2).

Implementation science communications·2026
Same author

Co-developing implementation strategies to support STEADI (Stopping Elderly Accidents, Deaths, and Injuries) for older adult fall prevention in outpatient physical therapy.

Innovation in aging·2026
Same author

Promoting inclusivity and partnership with recipients of health services: Short report on redesigning Engaging All Voices (previously Consumer Voice).

Research square·2026
Same author

Evaluating a tailored communication tool to increase advance care planning among Alaska Native and American Indian people in primary care: A type 1 hybrid effectiveness-implementation cluster randomized trial protocol.

Contemporary clinical trials·2026
Same author

Addressing Firearm Suicide Risk Reduction with an Online Patient Decision Aid Tailored to Women Veterans.

Journal of women's health (2002)·2026
Same author

Implementing STEADI for routine falls prevention of all older adults attending outpatient physical therapy: key partner perspectives.

Frontiers in health services·2026
Same journal

Pain care coordination in the Veterans Health Administration: a rapid qualitative analysis of care coordinator experiences.

Frontiers in health services·2026
Same journal

Oral health reception and risk classification protocol: development and validation in a dental emergency service.

Frontiers in health services·2026
Same journal

Peer support to address mental health, social determinants of health, financial wellness, and reentry navigation.

Frontiers in health services·2026
Same journal

Practical model for workforce development and community engagement in the public health laboratory.

Frontiers in health services·2026
Same journal

One health approach to chagas disease: a systematic review on the integration of human, animal, and environmental health.

Frontiers in health services·2026
Same journal

Strengthening health systems in low and middle-income countries: performance determinants and pathways to universal health coverage.

Frontiers in health services·2026
See all related articles

Related Experiment Video

Updated: Mar 24, 2026

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.8K

Hybrid type 1 effectiveness-implementation studies: why and how to do them.

Jure Baloh1, Sara J Landes2,3, Jeffrey L Smith3

  • 1Department of Health Policy and Management, University of Arkansas for Medical Sciences, Little Rock, AR, United States.

Frontiers in Health Services
|March 23, 2026
PubMed
Summary
This summary is machine-generated.

Effectiveness-implementation hybrid type 1 studies integrate implementation science into intervention research. This guidance helps design studies to improve intervention adoption and impact in real-world settings.

Keywords:
hybrid effectiveness-implementationhybrid type 1implementationmethodological guidanceresources

More Related Videos

Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities
10:26

Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities

Published on: September 11, 2021

4.5K
Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages
06:04

Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages

Published on: March 24, 2023

932

Related Experiment Videos

Last Updated: Mar 24, 2026

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.8K
Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities
10:26

Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities

Published on: September 11, 2021

4.5K
Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages
06:04

Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages

Published on: March 24, 2023

932

Area of Science:

  • Implementation Science
  • Health Services Research
  • Public Health

Background:

  • Effectiveness-implementation hybrid type 1 studies balance intervention effectiveness with implementation factors.
  • Integrating implementation aims enhances intervention speed, quality, sustainment, and scale.
  • Maximizing population health impact requires effective implementation in routine practice.

Purpose of the Study:

  • Provide methodological guidance for designing and conducting the implementation aims of hybrid type 1 studies.
  • Summarize existing knowledge and introduce new considerations for hybrid type 1 approaches.
  • Offer tools and resources for planning and designing hybrid type 1 studies.

Main Methods:

  • Guidance structured around three core goals for implementation aims.
  • Goal 1: Explain intervention implementation within the effectiveness trial.
  • Goals 2 & 3: Explore and examine stakeholder perceptions to inform research and the trial.

Main Results:

  • Hybrid type 1 approaches are versatile, applicable to various research designs, interventions, and settings.
  • Distinct research questions and design considerations (timing, sampling, data collection) are outlined for each goal.
  • The article presents practical tools and resources for study planning and design.

Conclusions:

  • Hybrid type 1 studies are crucial for translating research into practice and improving population health.
  • Effective design of implementation aims is key to maximizing the impact of interventions.
  • This guidance supports researchers in conducting robust effectiveness-implementation hybrid type 1 studies.