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Characterization of the Childhood Exposome with High-Resolution Mass Spectrometry
Taylor Teitelbaum1, Emily Werder2, Yun-Chung Hsiao3
1Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
Childhood chemical exposures, or the exposome, were analyzed using mass spectrometry. Higher household income was linked to lower levels of certain chemical exposures in children.
Area of Science:
- Environmental Health
- Pediatric Toxicology
- Analytical Chemistry
Background:
- Chemical exposures pose risks, particularly to children due to their developmental plasticity.
- Understanding the early life exposome is crucial for assessing environmental health impacts.
Purpose of the Study:
- To characterize the early life exposome in children.
- To investigate the relationship between chemical exposures and household income.
Main Methods:
- Analyzed 438 urine samples from 187 children using liquid chromatography-mass spectrometry (LC-MS).
- Integrated exposomics data with demographic information, focusing on household income.
Main Results:
- Identified 85 chemical compounds significantly associated with household income.
- Common exposure sources included food, plants, endogenous production, animals, cosmetics, and household products.
Conclusions:
- High-resolution mass spectrometry is effective for profiling the early life exposome.
- Exposomics can reveal connections between chemical exposures and demographic factors like income.
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