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Updated: Mar 25, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
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Unannotated noncoding transcripts as a source of intratumor heterogeneity in malignant cell states

Xiaolan Zhou1,2, Limin Lin1, Yu Chen1

  • 1State Key Laboratory of Genetic Engineering, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, Center for Evolutionary Biology, Shanghai Engineering Research Center of Industrial Microorganisms, School of Life Sciences, Fudan University, Shanghai, 200438, China.

Science China. Life Sciences
|March 23, 2026
PubMed
Summary

Researchers discovered thousands of unannotated transcripts linked to cancer cell diversity and treatment failure. Epigenetic activation of these transcripts may drive intratumor heterogeneity (ITH) in various cancers.

Keywords:
epigeneticintratumor heterogeneityscRNA-sequnannotated PAS peak-associated transcripts

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