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Isolated Premature Menarche in a 17-Month-Old: A Case Report
Dewi Rani Pelitawati1, Artha Falentin Putri Susilo1,2, Anita Rachmawati1,2
1Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.
The American Journal of Case Reports
|March 23, 2026
Summary
Vaginal bleeding in young girls can be concerning, but isolated premature menarche is a rare, benign condition. Careful evaluation is key to distinguish it from other causes and ensure appropriate care.
Area of Science:
- Pediatric Endocrinology
- Gynecology
Background:
- Vaginal bleeding in prepubertal girls is uncommon and requires thorough investigation.
- Precocious puberty involves early sexual development before age 8, while isolated premature menarche presents with bleeding alone.
Purpose of the Study:
- To present a case of isolated premature menarche in a young infant.
- To highlight the importance of differentiating this benign condition from other causes of vaginal bleeding in prepubertal girls.
Main Methods:
- A case report of a 17-month-old female infant with recurrent vaginal bleeding.
- Comprehensive evaluation including physical examination, hormonal assays, thyroid function tests, bone age assessment, platelet function testing, and pelvic ultrasonography.
- Exclusion of local, endocrine, and systemic etiologies.
Main Results:
- The infant presented with monthly vaginal bleeding for 3 months.
- All investigations, including hormonal levels and imaging, were consistent with a prepubertal state, ruling out precocious puberty or other pathologies.
- A diagnosis of isolated premature menarche was established after excluding other causes.
Conclusions:
- Menstrual-like vaginal bleeding in prepubertal girls necessitates a systematic evaluation.
- Recognizing isolated premature menarche as a benign entity is crucial to prevent unnecessary interventions and guide appropriate follow-up.
