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Updated: Jun 5, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Prehospital Trauma Labeling Delays Acute Stroke Reperfusion: A Matched-Pair Analysis

Nirav R Bhatt1, Abdullah M Al-Qudah1, John Bielanin2

  • 1UPMC Stroke Institute, Department of Neurology, University of Pittsburgh School of Medicine, PA (N.R.B., A.M.A.-Q., M.F.D., M.T.S., M.R., A.R.A.-B., R.G.N.).

Stroke
|March 23, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
emergency care, prehospitalischemic strokethrombectomythrombolytic therapy

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...