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Dynamic Relationship Between Sleep Patterns and Behavioral and Psychological Symptoms of Dementia: Longitudinal
Eunhee Cho1, Sinwoo Hwang1,2, Minhee Yang1
1Mo-Im Kim Nursing Research Institute, College of Nursing, Yonsei University, Seoul, Republic of Korea.
JMIR Aging
|March 23, 2026
Summary
Sleep disturbances and behavioral symptoms of dementia in older adults create a vicious cycle. Addressing sleep issues is crucial for managing dementia symptoms and improving quality of life.
Area of Science:
- Gerontology
- Neuroscience
- Sleep Medicine
Background:
- Behavioral and psychological symptoms of dementia (BPSD) are linked to increased caregiver burden and mortality.
- A reciprocal relationship between sleep disturbances and BPSD is plausible, necessitating time series analysis for temporal dynamics.
Purpose of the Study:
- To investigate the dynamic interdependencies between sleep disturbances and BPSD in older adults.
- To explore the temporal relationships and causality between specific sleep parameters and BPSD.
Main Methods:
- A 14-day panel vector autoregressive model was employed to analyze daily interactions.
- Data from 154 older adults with dementia were collected using wrist actigraphy for sleep and caregiver diaries for BPSD.
Main Results:
- Increased nighttime awakenings predicted subsequent irritability and appetite disorders.
- Delusions and irritability from the previous day influenced total sleep time, wake after sleep onset, and number of awakenings.
- Bidirectional Granger causality was found between irritability and the number of awakenings.
Conclusions:
- The relationship between BPSD and sleep patterns is a dynamic, cyclical process.
- Early interventions targeting BPSD and sleep disturbances are essential.
- Prioritizing strategies to enhance sleep quality is critical for managing dementia.
Keywords:
behavioral and psychological symptomsdementiagranger causalitypanel vector autoregressive modelsleepMore Related Videos
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