[Study of the thyroid function by the I-M TRH test (2 mg) (author's transl)]

The responses of TSH, T3 and T4 to intramuscular administration of 2 mg of TRH were compared in the same subjects to those observed after intravenous injection of 200 microgram of TRH. In 12 normal subjects the TSH and T3 peaks were significantly higher after intramuscular injection. There was no difference in T4 levels. In 15 patients: 5 toxic adenomas after surgery and 10 Graves' disease after treatment the results were comparable for TSH and T3 by the two routes.