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Related Experiment Video

Updated: Mar 25, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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G-ALPS: An index for evaluating cognitive decline and aging using diffusion tensor imaging.

Ahmadali Jamali1, Majid Abbasi Sisara1, Elahe Kazemi Nasab1

  • 1Medical Biology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|March 24, 2026
PubMed
Summary
This summary is machine-generated.

The new G-Along Perivascular Space (G-ALPS) index, derived using genetic programming, shows stronger correlations with cognitive measures and enhanced sensitivity to aging and sleep disorders compared to the ALPS index.

Keywords:
ALPSAgingAlzheimer's diseaseDTIGlymphatic systemMCISleep disorder

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Area of Science:

  • Neuroimaging
  • Biomedical Engineering
  • Neurology

Background:

  • Glymphatic system dysfunction is linked to cognitive decline in neurodegenerative diseases like Alzheimer's disease (AD).
  • Accurate assessment of glymphatic function is crucial for understanding and managing these conditions.

Purpose of the Study:

  • To introduce and validate the G-Along Perivascular Space (G-ALPS) index, an optimized metric for assessing glymphatic system function.
  • To evaluate the G-ALPS index's performance against the existing ALPS index using diffusion tensor imaging (DTI) data.

Main Methods:

  • Developed the G-ALPS index using Genetic Programming, an optimized version of the ALPS index.
  • Analyzed 217 diffusion tensor imaging (DTI) samples from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and Human Connectome Project (HCP) datasets.

Main Results:

  • The G-ALPS index demonstrated superior correlation with cognitive measures (MMSE, CDR, FAQ) compared to ALPS.
  • G-ALPS showed significantly enhanced sensitivity in detecting aging effects across AD, MCI, and control groups.
  • Improved correlation was observed between G-ALPS and sleep quality measures (MMSE, PSQI).

Conclusions:

  • The G-ALPS index shows promise as an indirect quantitative metric for assessing glymphatic system function or dysfunction.
  • This optimized index may offer improved insights into cognitive decline associated with neurodegeneration, aging, and sleep disorders.