Correlation Between SII and Lymphocyte Subsets in Gastric Cancer Patients and Its Prognostic Importance

Area of Science:

• Oncology
• Immunology
• Biomarkers

Background:

• The systemic immune-inflammation index (SII) reflects systemic inflammation.
• Lymphocyte subsets are crucial components of the immune system.
• Understanding the interplay between inflammation and immunity is vital in cancer research.

Purpose of the Study:

• To investigate the correlation between the systemic immune-inflammation index (SII) and lymphocyte subsets in gastric cancer.
• To assess the clinical significance and prognostic value of SII in gastric cancer patients.

Main Methods:

• Retrospective analysis of clinical and laboratory data from 95 gastric cancer patients and 44 healthy controls.
• Statistical analyses included Chi-square, Spearman correlation, Kaplan-Meier curves, log-rank test, and Cox regression.
• Evaluation of SII's diagnostic and prognostic capabilities.

Main Results:

• Gastric cancer patients exhibited significantly higher SII and lower counts of CD3+, CD4+, CD8+ T cells, and B cells compared to controls.
• SII demonstrated high diagnostic value for gastric cancer (AUC=0.850) and correlated positively with TNM staging.
• Elevated SII and reduced CD4+ T cell counts were associated with shorter survival, with SII identified as an independent risk factor for poor prognosis.

Conclusions:

• The systemic immune-inflammation index (SII) is strongly correlated with CD4+ T cells in gastric cancer.
• An elevated SII serves as a significant independent risk factor for poor prognosis in gastric cancer patients.