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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
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Psychometric Validation of the QLQ-NMIBC24 in Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer.

Charles C Peyton1, Rahul Dhanda2, Tom Burke3,4

  • 1Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA.

Research and Reports in Urology
|March 24, 2026
PubMed
Summary
This summary is machine-generated.

The EORTC QLQ-NMIBC24 questionnaire shows reliable measurement properties for patients with low-grade, intermediate-risk non-muscle invasive bladder cancer (LG-IR-NMIBC). This study proposes minimal clinically important difference (MCID) thresholds to interpret health-related quality of life (HRQoL) changes.

Keywords:
EORTC questionnairesHRQoLLG-IR-NMIBCbladder cancerminimal clinically important differencepsychometric validation

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Area of Science:

  • Oncology
  • Health Outcomes Research
  • Psychometrics

Background:

  • Non-muscle invasive bladder cancer (NMIBC) significantly impacts patient quality of life.
  • Accurate measurement of health-related quality of life (HRQoL) is crucial for evaluating NMIBC treatments.
  • The EORTC QLQ-NMIBC24 is a disease-specific tool for assessing HRQoL in NMIBC patients.

Purpose of the Study:

  • To evaluate the psychometric properties of the EORTC QLQ-NMIBC24 questionnaire.
  • To establish distribution-based minimal clinically important difference (MCID) thresholds for the EORTC QLQ-NMIBC24 in patients with low-grade, intermediate-risk NMIBC (LG-IR-NMIBC).

Main Methods:

  • Psychometric evaluation of the EORTC QLQ-NMIBC24 in 510 LG-IR-NMIBC patients from two Phase 3 trials (ATLAS and ENVISION).
  • Assessment included internal consistency, item convergence, known-groups validity, test-retest reliability, and responsiveness to clinical change.
  • Distribution-based MCID thresholds were calculated, and anchor-based analyses were explored.

Main Results:

  • The EORTC QLQ-NMIBC24 demonstrated good convergent validity and acceptable internal consistency for most domains.
  • Test-retest reliability was generally good for Urinary Symptoms and Sexual Function.
  • Selected domains showed responsiveness to clinical change, with distribution-based MCID estimates ranging from 4.37 to 16.29.

Conclusions:

  • The EORTC QLQ-NMIBC24 is a valid, reliable, and interpretable instrument for assessing HRQoL in LG-IR-NMIBC patients.
  • The proposed distribution-based MCID thresholds can aid in interpreting meaningful HRQoL changes.
  • Further anchor-based studies are recommended to confirm MCID values for clinical practice.