Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

1.5K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

630
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
630
Cancer Prevention02:59

Cancer Prevention

8.7K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.7K
Cancer Prevention02:59

Cancer Prevention

3.0K
3.0K
Cancer02:18

Cancer

55.6K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
55.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

5.1K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CTA-positive, angiography-negative lower GI bleeding: an institutional imaging-guided management algorithm.

Emergency radiology·2026
Same author

Acquiring Weak Annotations for Tumor Localization in Temporal and Volumetric Data.

Machine intelligence research (Beijing)·2026
Same author

Emphysematous cystitis: imaging patterns and diagnostic approach on CT.

Emergency radiology·2026
Same author

Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction.

bioRxiv : the preprint server for biology·2026
Same author

From Bench to Bedside: The Path Toward Real-World Translation for Artificial Intelligence in Pancreatic Cancer Detection.

Korean journal of radiology·2026
Same author

Altered renal corticomedullary differentiation on CT, Part I: A pictorial review of non-neoplastic causes.

Emergency radiology·2026

Related Experiment Video

Updated: Mar 27, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
10:51

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

4.7K

Hyperplasia Functions as a Link between Obesity and Cancer.

Sophie Pénisson1,2,3,4, Maren Weischer5, Lu Li6

  • 1CNRS, LAMA UMPR8050, Université Paris Est Creteil, Université Gustave Eiffel, Creteil, France.

Cancer Research
|March 24, 2026
PubMed
Summary
This summary is machine-generated.

Obesity increases organ size, primarily through cell proliferation (hyperplasia), raising cancer risk. Larger organs in obese individuals correlate with a higher likelihood of developing cancer.

More Related Videos

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice
05:34

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Published on: January 24, 2025

3.3K
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

5.3K

Related Experiment Videos

Last Updated: Mar 27, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
10:51

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

4.7K
Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice
05:34

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Published on: January 24, 2025

3.3K
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

5.3K

Area of Science:

  • Oncology
  • Metabolic disease
  • Cell biology

Background:

  • Obesity is a known risk factor for multiple cancers.
  • The biological mechanisms linking obesity to cancer are not fully understood.

Purpose of the Study:

  • To investigate the relationship between body mass index (BMI) and organ size.
  • To determine the cellular mechanisms of organ enlargement in obesity.
  • To assess the correlation between organ volume and cancer risk.

Main Methods:

  • Measured liver, pancreas, and kidney volumes in 747 adults across a wide BMI range.
  • Quantified kidney cell numbers using autopsy and biopsy data.
  • Correlated organ volume ratios with cancer risk.

Main Results:

  • Higher BMI strongly correlated with increased liver, kidney, and pancreas volumes.
  • Kidney enlargement was attributed to 61% hyperplasia and 39% hypertrophy.
  • Increased organ volume significantly correlated with elevated cancer risk across organs.

Conclusions:

  • Obesity-induced organ expansion, mainly via hyperplasia, increases the number of cells vulnerable to malignant transformation.
  • This provides a mechanistic link between obesity and cancer risk, complementing other known pathways.