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Updated: Mar 27, 2026
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Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
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SRPRB can regulate proliferation and migration in Triple-Negative breast cancer cells
Huan Liu1, Yi-Xuan Huo1, Ying Rao1
1School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise 530005, Guangxi, China.
Gene
|March 24, 2026
Summary
Signal recognition particle receptor subunit beta (SRPRB) is highly expressed in triple-negative breast cancer (TNBC). SRPRB inhibition suppresses TNBC cell growth, migration, and invasion, indicating its potential as a therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
Background:
- Triple-negative breast cancer (TNBC) presents a poor prognosis among breast cancer subtypes.
- The role of signal recognition particle receptor subunit beta (SRPRB) in TNBC tumorigenesis requires further elucidation.
Purpose of the Study:
- To investigate the expression and function of SRPRB in TNBC.
- To evaluate SRPRB as a prognostic biomarker and therapeutic target for TNBC.
Main Methods:
- Bioinformatics analysis, qRT-PCR, and Western blot were used to assess SRPRB expression.
- In vitro assays (CCK-8, colony formation, Transwell, wound healing, flow cytometry, Hoechst staining) evaluated SRPRB's impact on TNBC cell behavior.
- WNT signaling pathway was analyzed via Western blot.
Main Results:
- SRPRB was significantly upregulated in TNBC tissues and cell lines.
- High SRPRB expression correlated with poor overall survival and recurrence-free survival in TNBC patients.
- SRPRB knockdown inhibited proliferation, migration, and invasion, while inducing apoptosis and suppressing the WNT pathway in TNBC cells.
Conclusions:
- SRPRB serves as a potential prognostic biomarker for TNBC.
- Targeting SRPRB demonstrates therapeutic potential by inducing apoptosis and inhibiting proliferation and metastasis.
- SRPRB's role in WNT pathway regulation highlights its significance in TNBC progression.
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