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Intrauterine Drug Delivery Systems01:21

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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
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The vulva encompasses the external structures of the female reproductive system. At the forefront is the monpubis, a cushion of fatty tissue atop the pubic bone. Once puberty sets in, this area typically grows hair. Extending from just behind the mons pubis are the labia majora (labia = 'lips'; majora = 'larger'), which are larger skin fs olds coated with hair. Nestled within are the labia minora (labia = 'lips'; minora = 'smaller'), which are thinner, more...
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3D Printed Vaginal Rings For Contraceptive Applications: Materials, Mechanisms, and Opportunities.

Riya Patel1, Paranshi Jadeja2, Shailvi Shah3

  • 1Department of Pharmaceutical Technology, LJ Institute of Pharmacy, L J University, Near Sarkhej-Sanand Circle, LJ CampusOff. S.G. Road, Ahmedabad, 382210, India.

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3D printing enables personalized vaginal rings for contraception. This technology offers scalable, flexible manufacturing, potentially revolutionizing patient-centered birth control solutions and improving adherence.

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Area of Science:

  • Biomedical Engineering
  • Reproductive Health
  • Materials Science

Background:

  • Half of global births are unplanned, despite available contraception.
  • Intravaginal rings (IVRs) offer consistent drug release and improved adherence.
  • Current IVR manufacturing lacks design flexibility and rapid prototyping.

Purpose of the Study:

  • To explore the potential of 3D printing for creating personalized intravaginal rings.
  • To assess the viability of 3D-printed IVRs for contraception and dual-purpose applications.
  • To examine future advancements in 3D-printed vaginal ring technology.

Main Methods:

  • Review of additive manufacturing techniques, particularly 3D printing, for IVR fabrication.
  • Analysis of material selection, focusing on biocompatible and biodegradable polymers.
  • Evaluation of printing methods like fused deposition modeling and stereolithography.
  • Characterization of mechanical strength, stability, and mucoadhesion of 3D-printed devices.

Main Results:

  • 3D printing allows for flexible design and customization of vaginal rings.
  • Viability demonstrated through functional, structural, mechanical, and mucoadhesive characterization.
  • Exploration of multidrug systems and combined STI/HIV prevention with contraception.
  • Scalable and adaptable manufacturing processes for personalized contraceptive solutions.

Conclusions:

  • 3D printing offers a revolutionary approach to manufacturing patient-centered vaginal rings.
  • This technology enhances personalization, flexibility, and scalability in contraceptive device production.
  • Future developments include AI-guided design and 4D printing, addressing clinical translation and regulatory aspects.