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Lessons learned from conducting a multi-center lower urinary tract physiology study: the LURN experience
Claire C Yang1, James A Hokanson2, Anna C Kirby3
1Department of Urology, University of Washington, Seattle, WA.
Continence (Amsterdam, Netherlands)
|March 25, 2026
Summary
This multi-center study evaluated bladder and urethra function in women, detailing logistics and technical aspects for future lower urinary tract (LUT) research. Lessons learned offer insights for complex clinical trials.
Area of Science:
- Urology
- Clinical Research Methodology
Background:
- Lower urinary tract (LUT) physiology research is complex and resource-intensive.
- Multi-center studies require robust logistical and technical planning.
Purpose of the Study:
- To document the logistics and technical considerations for a multi-center protocol.
- To evaluate sensory and motor function of the bladder and urethra.
- To include women with urgency, urgency with incontinence, and controls.
Main Methods:
- Described study network organization and infrastructure.
- Detailed technical training methods and data quality control.
- Utilized a multi-center protocol for lower urinary tract (LUT) testing.
Main Results:
- Enrolled 105 participants across 6 sites during the COVID pandemic.
- All participants completed testing with no adverse events and had evaluable data.
- One cohort did not reach target enrollment for statistical analysis.
Conclusions:
- Large, multi-site LUT physiology studies are complex and prone to challenges.
- Lessons learned from the LURN-Organ study can guide future clinical research.
- Successful navigation of unprecedented circumstances offers valuable insights for investigators.
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