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[Sinonasal and petrous bone fungal infections]

Florian Chatelet1, Marjolaine Morgand2, Claire Rouzaud3

  • 1Service d'ORL, hôpital Lariboisière, AP-HP, UMR 1153 ECSTRA, Université Paris Cité, Paris, France.

La Revue Du Praticien
|March 25, 2026
PubMed

Insights

Rare fungal infections of the sinuses and petrous bone are life-threatening, primarily affecting immunocompromised individuals. Early diagnosis via biopsy and multidisciplinary treatment combining antifungals and surgery are crucial for managing these severe Aspergillus and Mucorales infections.

Area of Science:

  • Infectious Diseases
  • Mycology
  • Otolaryngology

Background:

  • Sinonasal and petrous bone fungal infections are rare but life-threatening conditions.
  • These infections primarily affect immunocompromised patients, with specific fungal agents linked to underlying conditions (e.g., Aspergillus in hematological diseases, Mucorales in diabetes).

Purpose of the Study:

  • To highlight the critical nature of sinonasal and petrous bone fungal infections.
  • To emphasize the importance of early diagnosis and multidisciplinary management strategies.

Main Methods:

  • Diagnosis relies on early surgical biopsies and essential histopathological analysis.
  • Treatment involves a multidisciplinary approach, including antifungal therapy and etiological care.

Main Results:

  • Invasive fungal sinusitis can present acutely (e.g., invasive aspergillosis, rhino-orbito-cerebral mucormycosis) or chronically.
  • Petrous bone fungal infections resemble bacterial necrotizing otitis externa, often caused by Aspergillus.

Conclusions:

  • Prompt diagnosis through histopathology is vital for effective therapeutic intervention.
  • Multidisciplinary management, potentially including surgical debridement for mucormycosis, is key to patient outcomes.
Keywords:
aspergillosismycosisotomycosissick sinus syndrome

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