Related Experiment Video
Updated: Mar 27, 2026
05:14
Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
Published on: August 11, 2023
1.7K
CENTENARIAN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
Vittorio Capuano1, Serena Fragiotta2, Jeremy Abadou1
1Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
Retina (Philadelphia, Pa.)
|March 25, 2026
Summary
Centenarian patients with neovascular age-related macular degeneration (AMD) can maintain vision with long-term anti-VEGF therapy. Tailored management is crucial for these elderly individuals.
Area of Science:
- Ophthalmology
- Geriatric Medicine
- Retinal Diseases
Background:
- Neovascular age-related macular degeneration (AMD) is a leading cause of vision loss in older adults.
- Centenarians represent a unique and understudied population with AMD.
- Understanding the characteristics of AMD in this age group is essential for effective treatment.
Purpose of the Study:
- To describe the clinical features of exudative neovascular age-related macular degeneration (AMD) in patients aged 100 years and older.
- To evaluate visual outcomes and influencing factors in centenarian AMD patients.
Main Methods:
- Retrospective, longitudinal study at two European retinal referral centers.
- Reviewed clinical data of neovascular AMD patients who were at least 100 years old at last follow-up.
- Analyzed best corrected visual acuity (BCVA), type of macular neovascularization (MNV), and associated pathologies.
Main Results:
- Study included 28 eyes from 14 centenarian patients (mean age at last follow-up: 102.4 years).
- 86% presented with type 1 macular neovascularization (MNV).
- 57% of eyes showed stable or improved BCVA, with a mean final BCVA of 20/100. Higher baseline BCVA and thicker choroids correlated with better outcomes. Macular hemorrhage and atrophy were linked to poorer vision.
Conclusions:
- Centenarian patients with neovascular AMD can achieve stable or improved vision with sustained anti-VEGF treatment.
- Long-term anti-VEGF therapy is a viable option for vision maintenance in this extreme age group.
- Individualized management strategies are necessary to address the specific needs and challenges of centenarians with neovascular AMD.
Keywords:
age-related macular degenerationantivascular endothelial growth factorcentenarianmacular neovascularizationMore Related Videos
Related Concept Videos
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
315
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
315
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
802
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
802
01:27Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
335
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
335
01:28Angle Closure Glaucoma: Treatment
1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
324
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
324