Related Experiment Video
Updated: Jul 13, 2026
26:48
Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
18.9K
Anti-GluK2 antibody-associated autoimmune encephalomyelitis with delayed MRI abnormalities: case report
Weipeng Liu1, Lei He2, Zehong Yang3
1Department of Intensive Care Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Neuroscience
|March 25, 2026
Summary
This case study highlights delayed MRI findings in anti-GluK2 antibody-associated autoimmune encephalomyelitis, a rare neurological disorder. Early diagnosis and immunotherapy are crucial for patient recovery.
Area of Science:
- Neurology
- Immunology
Background:
- Anti-GluK2 antibody-associated autoimmune encephalomyelitis is a rare neurological disorder.
- Delayed radiological manifestation is a characteristic, yet under-recognized, feature.
Purpose of the Study:
- To document the first case of delayed radiological manifestation in anti-GluK2 antibody-associated autoimmune encephalomyelitis.
- To emphasize the clinical significance of this rare disorder.
Main Methods:
- A comprehensive evaluation of a 20-year-old female patient with neurological symptoms.
- Inclusion of blood and CSF analyses, EEG, and serial brain and spinal cord MRI.
- Treatment with intravenous methylprednisolone and immunoglobulin therapy.
Main Results:
- Diagnosis of anti-GluK2 antibody-associated autoimmune encephalomyelitis.
- Initial MRI scans were unremarkable; delayed abnormalities emerged one month later.
- Clinical improvement was observed following immunotherapy.
Conclusions:
- Anti-GluK2 antibody-associated encephalomyelitis can present with delayed spinal MRI findings.
- Elevated serum IgE may play a role in the pathogenesis.
- Prompt diagnosis and immunotherapy are vital for favorable clinical outcomes.
Keywords:
Anti-GluK2 antibodiesAutoimmune encephalomyelitisDelayed MRI abnormalitiesSpinal cord involvementMore Related Videos
Related Concept Videos
01:19Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...