Related Experiment Video

Updated: Mar 27, 2026

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
08:32

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

Published on: January 17, 2025

1.4K

The anatomy and molecular inventory of Staphylococcus aureus abscesses

Kyle T Enriquez1, Eric P Skaar2

  • 1Vanderbilt Medical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

Trends in Microbiology
|March 25, 2026
PubMed

Insights

Staphylococcus aureus forms abscesses by creating protective communities. Understanding host and pathogen factors in abscess formation is key to improving Staphylococcus aureus infection outcomes.

Area of Science:

  • Microbiology
  • Immunology
  • Pathogenesis

Background:

  • Staphylococcus aureus is a versatile opportunistic pathogen infecting diverse body sites.
  • Abscesses are host-pathogen structures critical to S. aureus pathogenesis.
  • Staphylococcal abscess communities are linked to severe infection outcomes.

Purpose of the Study:

  • To review recent discoveries in S. aureus abscess formation across organ systems.
  • To highlight host and pathogen determinants influencing abscess development.
  • To enhance understanding of S. aureus pathogenesis through abscess research.

Main Methods:

  • Literature review of recent findings on S. aureus abscesses.
  • Analysis of host-pathogen interactions within abscess microenvironments.
  • Synthesis of data on determinants of abscess formation and outcomes.

Main Results:

  • Abscesses involve complex host-derived extracellular matrices and immune cells.
  • Host and pathogen adaptations shape abscess characteristics and infection progression.
  • Recent research reveals key factors driving abscess formation and severity.

Conclusions:

  • Abscess formation is a critical aspect of S. aureus pathogenesis.
  • Understanding host-pathogen dynamics in abscesses is vital for therapeutic strategies.
  • Further research into abscess determinants can improve S. aureus infection management.
Keywords:
Staphylococcus aureusabscessbacterial pathogenesishost–microbe interfacestaphylococcal abscess community

More Related Videos

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.8K
Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds06:36

Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds

Published on: September 8, 2021

3.3K

Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
39
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
69
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
26
Bacterial Phylum Actinobacteria01:30

Bacterial Phylum Actinobacteria

Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
840
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
9.1K
Special Staining Techniques01:13

Special Staining Techniques

Specialized staining techniques play a vital role in microbiology by enabling the visualization of specific bacterial structures that remain undetectable with standard microscopy methods. These techniques not only enhance the structural visualization of bacterial cells but also provide critical insights into their pathogenicity and classification. Additionally, they support diagnostic and research endeavors in microbiology by identifying key bacterial features.Capsule Staining for Virulence...
1.6K