Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Skin Microbiota

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...

Introduction to the Human Microbiota

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Presuming pathways of sea turtles using stable isotopes from shells of epibiont barnacles.

Marine environmental research·2026

Same author

Understanding How Older Adults Comprehend Simple Comparative Sentences in a Predicate-Final Language.

Journal of speech, language, and hearing research : JSLHR·2026

Same author

Association of METS-IR with breast cancer risk: a large-scale retrospective cohort study of Korean women.

BMC public health·2026

Same author

Evaluation of the Preclinical and Clinical Obesity Framework for Risk Stratification of Major Adverse Liver Outcomes.

Mayo Clinic proceedings·2026

Same author

Battery minerals for neural inhibition.

Nature materials·2026

Same author

A complete human pancreatic cancer genome.

bioRxiv : the preprint server for biology·2026

Same journal

Bacterial spores as a modular platform for the production of amyloids for materials.

Trends in biotechnology·2026

Same journal

The oriGen case and Mexico's regulatory blind spots in genomic biobanking.

Trends in biotechnology·2026

Same journal

A caspase-3-activated protein expression system for apoptosis visualization and apoptosis-pyroptosis conversion to boost antitumor activity.

Trends in biotechnology·2026

Same journal

Over 4 months of ethylene production using solid-state photosynthetic cell factories.

Trends in biotechnology·2026

Same journal

Closing the nitrogen loop in groundwater with biohybrid technologies.

Trends in biotechnology·2026

Same journal

Engineering environmental bacteria for whole-cell PET hydrolysis and assimilation.

Trends in biotechnology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 27, 2026

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

Published on: July 4, 2018

In vitro platforms for reconstructing skin-microbiome interactions.

Jimin Park¹, Jeongmin Kim¹, Sungchan Cho¹

¹Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.

Trends in Biotechnology

|March 25, 2026

Summary

This summary is machine-generated.

Researchers are developing in vitro skin models to study the skin microbiome and its effects on host health. These models aid in understanding skin-microbiome interactions and developing new live biotherapeutics for skin diseases.

Keywords:

host–microbiome interactions in vitro platforms live biotherapeutics skin microbiome skin-on-a-chip synthetic biology

More Related Videos

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

Related Experiment Videos

Last Updated: Mar 27, 2026

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

Published on: July 4, 2018

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

Area of Science:

Microbiology
Dermatology
Systems Biology

Background:

The skin microbiome plays a crucial role in host metabolic and immune functions.
In vitro platforms are being developed to study skin-microbiome and microbe-microbe interactions.
Standardized long-term coculture platforms for skin-microbiome research are lacking.

Purpose of the Study:

To review key components for modeling in vitro skin ecosystems.
To discuss the therapeutic potential of skin commensals.
To highlight advances in engineered live biotherapeutics for skin diseases.

Main Methods:

Review of existing literature on in vitro skin models.
Analysis of components for establishing in vitro skin ecosystems.
Discussion of therapeutic applications of skin commensals and live biotherapeutics.

Main Results:

In vitro skin models are essential for studying complex skin-microbiome interactions.
Skin commensals and engineered live biotherapeutics show promise for treating skin diseases.
Standardization of long-term coculture platforms is needed.

Conclusions:

In vitro skin-microbiome studies have significant translational value.
Further development of standardized platforms will accelerate research and therapeutic applications.
Engineered live biotherapeutics represent a promising frontier in dermatology.