Advances in Nanoparticle-Based Vitamin Delivery Systems for Precision Nutrition and Improved Bioavailability.
Sathvik Chennamsetty1, Mahesha Keerikkadu1, Akshay Shetty1
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
AAPS Pharmscitech
|March 26, 2026
Summary
Nanocarrier technology enhances vitamin delivery, improving bioavailability and overcoming limitations of traditional oral supplements. This approach offers a promising avenue for precision nutrition and better public health outcomes.
Area of Science:
- Nutritional Science
- Biotechnology
- Materials Science
Background:
- Vitamin deficiencies (D, A, E, K, B12, Folate) persist despite supplementation.
- Traditional oral vitamins suffer from low bioavailability due to poor solubility and digestive instability.
- Nanocarrier systems offer a solution to enhance vitamin solubility, stability, and targeted delivery.
Purpose of the Study:
- To review advancements in nanocarrier-based strategies for vitamin delivery.
- To examine nanoparticle uptake, absorption, and cellular trafficking mechanisms.
- To discuss improving vitamin pharmacokinetics, safety, and production challenges.
Main Methods:
- Review of current literature on nanocarrier-based vitamin delivery.
- Categorization of nanocarrier types: lipid nanoparticles, polymeric carriers, liposomes, protein/peptide carriers, inorganic materials.
- Analysis of nanoparticle interactions with mucosal barriers and cellular processes.
Main Results:
- Nanocarriers improve vitamin solubility and protect against degradation.
- Targeted delivery to the intestine or lymphatic system is facilitated.
- Various nanocarrier platforms show potential for enhanced vitamin bioavailability.
Conclusions:
- Nanocarrier-based vitamin delivery platforms are crucial for metabolic, skeletal, and immune health.
- These platforms represent a significant opportunity for precision nutrition.
- Advancements in nanocarriers hold potential to improve public health outcomes by addressing vitamin deficiencies.
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