Related Experiment Video
Updated: Mar 27, 2026

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
Published on: April 19, 2013
Polygenic Risk Score Predicts Prostate Cancer Risk Independent of Type 2 Diabetes
Guk Jin Lee1,2, Sang-Hyuk Jung3,4, Jonghyun Lee2
1Division of Medical Oncology, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Aims:
Type 2 diabetes mellitus (T2DM) has been inversely associated with prostate cancer (PrCa) risk. However, it remains unclear whether a polygenic risk score (PRS) for PrCa can effectively stratify risk among men with T2DM. The primary objective of this study was to assess whether a PrCa PRS predicts PrCa risk independently of T2DM status. The secondary objective was to evaluate potential mediating factors, including insulin-like growth factor-1 (IGF-1) and sex hormones.
Materials And Methods:
We analysed data from over 140 000 men in the UK Biobank and Penn Medicine Biobank. A PrCa PRS was constructed using summary statistics from a large-scale genome-wide association study. Cox proportional hazards models were used to evaluate the association between PRS and incident PrCa, adjusting for relevant covariates and testing for interaction by T2DM status. Additionally, sex hormones and IGF-1 levels were analysed to explore potential mediators.
Results:
T2DM was associated with a reduced incidence of PrCa. The PrCa PRS was significantly associated with PrCa risk regardless of T2DM status (p < 0.001), and men in the highest PRS category exhibited the greatest risk, especially among those without T2DM. IGF-1 levels were positively associated with PrCa risk among both diabetic and non-diabetic men, while sex hormone levels showed no significant association in men with T2DM. Adjusting for testosterone and IGF-1 did not attenuate the association between PRS and PrCa.
Conclusions:
PrCa PRS effectively stratifies risk among men with and without T2DM, highlighting the independent contribution of genetic susceptibility. Lower IGF-1 levels in T2DM patients may partly mediate the reduced PrCa risk, suggesting a possible biological mechanism underlying these observations.
More Related Videos
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Psychoneuroimmunology: Diabetes and Cancer
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Polygenic Traits

