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Published on: April 19, 2024
Case Report: Rare Community-Acquired Pneumonia with Concurrent Methicillin-Resistant Staphylococcus aureus and
Jiayuan Ye1, Lu Sun2, Dong Lv3
1Department of Infectious Diseases, Shangyu People's Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, People's Republic of China.
Abstract:
Cryptococcal pneumonia predominantly occurs in immunocompromised patients, but its incidence among immunocompetent individuals has been increasing in recent years. However, cases of co-infection with Cryptococcus neoformans and community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in immunocompetent hosts remain exceedingly rare. This study reports on a previously healthy 30-year-old male who presented with 20-days cough and 1-day fever. Through nanopore targeted sequencing (NTS) of bronchoalveolar lavage fluid (BLAF) and traditional microbial culture, he was ultimately diagnosed with a co-infection of C. neoformans and CA-MRSA. The patient showed significant improvement after treatment with oral linezolid (0.6 g twice daily) for 2 weeks and oral fluconazole (400 mg once daily) for 6 months. This case highlights that even immunocompetent individuals can simultaneously contract multiple community-acquired pathogens, while also underscoring the clinical utility of NTS in the early diagnosis of co-infections and detection of resistance genes.
Insights
A rare co-infection of Cryptococcus neoformans and community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) was diagnosed in an immunocompetent patient. Nanopore targeted sequencing aided early detection, leading to successful treatment.
Area of Science:
- Infectious Diseases
- Microbiology
- Genomics
Background:
- Cryptococcal pneumonia typically affects immunocompromised individuals.
- Increasing incidence of cryptococcal pneumonia in immunocompetent hosts.
- Co-infections with Cryptococcus neoformans and CA-MRSA in immunocompetent hosts are rare.
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