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Updated: Mar 27, 2026

Bioluminescent Bacterial Imaging In Vivo
Published on: November 4, 2012
Is deep brain imaging on the brink of transformation with a bioluminescence molecule?
Shumao Xu1, Farid Manshaii1, Jun Chen1
1Department of Bioengineering, University of California, Los Angeles, Los Angeles, USA.
Abstract:
Cephalofurimazine (CFz), when paired with Antares luciferase, shows superior blood-brain barrier permeability and enhanced imaging depth and clarity for deep brain imaging. This bioluminescence provides a less invasive method for real-time monitoring of deep brain activity, with the potential to advance targeted therapies and deepen our understanding of brain functions. Further molecular engineering and localized delivery can reduce the potential toxicity of CFz and enhance its efficacy for clinical deep brain imaging.
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