Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

1.8K
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
1.8K
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

339
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
339
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

455
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
455
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

1.2K
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
1.2K
Dialysis01:27

Dialysis

2.0K
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
2.0K
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

763
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
763

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics and outcomes of intensive care patients receiving metaraminol infusion-a retrospective observational cohort study.

Anaesthesia and intensive care·2026
Same author

Gastroenterology and critical care.

Current opinion in critical care·2026
Same author

Accelerated impact of alcohol-associated hepatitis on healthcare utilisation during the COVID-19 pandemic.

Internal medicine journal·2026
Same author

Thromboelastography to monitor anticoagulation in ICU patients receiving a continuous infusion of unfractionated heparin.

Journal of critical care·2026
Same author

Culture, ethics and clinical practice for intensivists managing end of life care: an Australian perspective.

Journal of intensive care·2026
Same author

Phoxilium® as a Phosphate-Sparing Solution for Continuous Renal Replacement Therapy in Paracetamol-Induced Acute Liver Failure.

Blood purification·2025

Related Experiment Video

Updated: Mar 27, 2026

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
16:19

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Published on: September 13, 2014

13.3K

Continuous renal replacement therapy in acute liver failure.

Caleb Fisher1,2, Stephen Warrillow1,2,3

  • 1Department of Critical Care, The University of Melbourne, Parkville 3010, Victoria, Australia.

World Journal of Critical Care Medicine
|March 26, 2026
PubMed
Summary

Continuous renal replacement therapy (CRRT) is vital for managing acute liver failure (ALF) by removing toxins like ammonia. Optimizing CRRT timing, dose, and duration may improve survival in ALF patients.

Keywords:
Acute liver failureAcute liver injuryCerebral oedemaContinuous renal replacement therapyHyperammonaemia

More Related Videos

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

3.2K
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

11.2K

Related Experiment Videos

Last Updated: Mar 27, 2026

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
16:19

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Published on: September 13, 2014

13.3K
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

3.2K
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

11.2K

Area of Science:

  • Nephrology
  • Hepatology
  • Critical Care Medicine

Background:

  • Acute liver failure (ALF) is a severe condition primarily affecting young adults, leading to rapid hepatic dysfunction and multi-organ failure.
  • Toxin accumulation, particularly ammonia, causes cerebral edema and intracranial hypertension in ALF patients.
  • Continuous renal replacement therapy (CRRT) is emerging as a critical intervention for ammonia removal in ALF.

Purpose of the Study:

  • To explore the multifaceted benefits of CRRT in ALF beyond renal replacement.
  • To examine the mechanisms, indications, and evidence supporting CRRT as a "metabolic-toxin-fluid" therapy in ALF.
  • To highlight the potential impact of CRRT parameters on patient survival.

Main Methods:

  • This review synthesizes current evidence on CRRT in ALF.
  • Mechanisms of ammonia removal and other benefits are discussed.
  • Indications and survival data related to CRRT in ALF are analyzed.

Main Results:

  • CRRT effectively clears toxins such as ammonia, mitigating cerebral edema and intracranial hypertension.
  • CRRT aids in managing acid-base balance, fever, and fluid overload in ALF.
  • Evidence suggests CRRT parameters (initiation timing, dose, duration) influence survival outcomes.

Conclusions:

  • CRRT should be considered a comprehensive "metabolic-toxin-fluid" therapy for ALF, not solely for renal failure.
  • Optimizing CRRT strategies is crucial for improving survival in ALF.
  • Further research into CRRT's role in ALF is warranted.