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Updated: Mar 27, 2026
Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma
Published on: January 22, 2022
Early Ovarian Teratoma Resection Improves Outcomes in Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Dual-Case
Xi Lan1,2, JiaYu Chen1, Yang Yang1
1Department of Obstetrics and Gynecology, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Nanning, Guangxi, 530022, People's Republic of China.
Objective:
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuroimmune disorder closely associated with ovarian teratomas, yet the prognostic impact of early surgical intervention requires further exploration. This dual-case analysis highlights the critical role of timely teratoma resection in improving clinical outcomes.
Case Presentation:
Case 1 involved a 34-year-old female presenting with psychiatric-dominant symptoms. A right salpingo-oophorectomy (pathology: immature teratoma) was performed 18 days post-onset, followed by rituximab therapy, resulting in full recovery with a modified Rankin Scale (mRS) score of 0. Case 2, a 16-year-old adolescent, underwent an initial laparoscopic ovarian teratoma resection (pathology: mature teratoma) 28 days post-onset. Residual tumor necessitated a second surgery (on day 95), leaving mild quadriparesis and ataxia with a mRS score of 2. Both cases remained recurrence-free during follow-up (17 and 14 months, respectively).
Conclusion:
Early surgical resection of ovarian teratomas is critical for favorable prognosis in anti-NMDAR encephalitis, halting antibody production and preventing irreversible neurological damage.
