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Related Experiment Video

Updated: Mar 27, 2026

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

Patient and Chondral Defect-Specific Characteristics an Associated Matrix-Induced Autologous Chondrocyte Implantation

Derrick M Knapik¹, Daniel C Touhey¹, S Ryan Pierson¹

¹Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

Orthopaedic Journal of Sports Medicine

|March 26, 2026

Summary

Matrix-induced autologous chondrocyte implantation (MACI) is a viable knee cartilage repair option. Patellar lesions and prior surgery increase MACI likelihood, while concurrent procedures decrease it.

Keywords:

MACI autologous chondrocyte implantation chondral restoration knee

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Last Updated: Mar 27, 2026

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

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Published on: May 21, 2013

Chondrogenic Pellet Formation from Cord Blood-derived Induced Pluripotent Stem Cells

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Published on: June 19, 2017

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Area of Science:

Orthopedics
Regenerative Medicine
Cartilage Repair

Background:

Focal chondral defects in the knee cause pain, swelling, and functional loss.
Matrix-induced autologous chondrocyte implantation (MACI) offers a promising treatment for knee cartilage defects.
Factors influencing MACI conversion after biopsy are not well-documented.

Purpose of the Study:

To identify patient and defect characteristics predicting MACI conversion after chondral biopsy.
To analyze factors associated with proceeding to MACI from a single institution.

Main Methods:

Retrospective review of prospectively collected data (June 2018-March 2025).
Included patients aged ≥15 with ICRS grade 2-4 knee chondral lesions undergoing biopsy.
Univariate and multivariate regression analyzed factors for MACI conversion.

Main Results:

28.8% of 104 patients proceeded to MACI after biopsy.
Patellar lesions (OR 18.85) and prior knee surgery increased MACI likelihood.
Concomitant procedures during biopsy (OR 0.22) decreased MACI likelihood.

Conclusions:

MACI is performed in a significant portion of patients biopsied for chondral lesions.
Patellar defects and prior surgery are key indicators for MACI.
Concurrent procedures during biopsy reduce the need for subsequent MACI.