Recent developments in asymmetric synthesis of cyclohepta[b]indole derivatives
Reena Jangir1, Jyothi Yadav1, Eldhose Iype2
1Department of Chemistry, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India. indresh.chemistry@gmail.com.
None:
Cyclohepta[b]indole derivatives constitute a prominent class of indole-annulated medium-sized ring systems that occur in diverse bioactive natural products and pharmaceutically relevant scaffolds. Their enantioselective construction, however, remains intrinsically challenging owing to conformational flexibility, transannular interactions, and unfavorable thermodynamic/entropic features associated with seven-membered ring formation. This review summarizes progress in emerging asymmetric methodologies that deliver chiral cyclohepta[b]indole frameworks, by highlighting advances in catalyst design, reaction efficiency, and stereocontrol, alongside mechanistic insights that rationalize selectivity trends and guide future development.
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