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Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

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The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
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Cranial Bones: Superior and Posterior View01:14

Cranial Bones: Superior and Posterior View

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The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
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Cranial Bones: Lateral View01:27

Cranial Bones: Lateral View

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The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
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Updated: Mar 28, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

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Craniosynostosis: Imaging and Surgical Implications.

Neetika Gupta1, Shivaprakash B Hiremath2, Daniel A Peters3

  • 1Department of Medical Imaging, Children's Hospital of Eastern Ontario, and Department of Radiology, Radiation Oncology and Medical Physics, University of Ottawa, 401 Smyth Rd, Ottawa, ON, Canada K1H 8L1.

Radiographics : a Review Publication of the Radiological Society of North America, Inc
|March 26, 2026
PubMed
Summary
This summary is machine-generated.

Craniosynostosis, the premature fusion of skull sutures, requires timely diagnosis and surgical intervention for optimal pediatric outcomes. Advanced imaging techniques improve accuracy while minimizing radiation exposure in evaluating this complex condition.

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Area of Science:

  • Pediatric Radiology
  • Craniofacial Surgery
  • Medical Genetics

Background:

  • Craniosynostosis involves early cranial suture fusion, causing abnormal skull shape and potential intracranial pressure (ICP) issues.
  • It can be isolated (nonsyndromic) or part of a genetic syndrome, influenced by gene mutations (e.g., FGFR, TWIST).
  • Secondary forms arise from systemic diseases and bone dysplasias.

Purpose of the Study:

  • To provide a comprehensive overview of craniosynostosis, covering embryology, causes, classification, and management.
  • To detail critical imaging findings and presurgical approaches for accurate diagnosis and planning.
  • To review surgical strategies, postoperative imaging, and long-term follow-up in multidisciplinary care.

Main Methods:

  • Review of embryologic development and cranial suture anatomy.
  • Discussion of multifactorial causes, syndromic vs. nonsyndromic classification.
  • Emphasis on imaging modalities (US, low-dose CT, MRI) for diagnosis and monitoring.

Main Results:

  • Imaging is crucial for diagnosis, differentiating mimics, surgical planning, and postoperative assessment.
  • Advanced imaging enhances accuracy while reducing radiation exposure in pediatric patients.
  • Timely surgical intervention and follow-up are vital for preventing complications and improving outcomes.

Conclusions:

  • Craniosynostosis management necessitates a multidisciplinary approach, integrating embryology, genetics, advanced imaging, and surgical expertise.
  • Early detection and intervention are key to ensuring adequate brain development and preventing long-term complications.
  • Systematic follow-up is essential for monitoring outcomes and minimizing the need for revision surgeries.