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Risk of Malnutrition in Patients With Pancreatic Cancer
Olivia Di Vincenzo1, Elena Azzini2, Angela Polito2
1Department of Experimental Medicine, Sapienza University of Rome, Rome, 00185, Italy.
Nutrition Reviews
|March 26, 2026
Summary
Malnutrition risk is common in pancreatic cancer (PaC) patients and linked to worse outcomes. Consistent screening and intervention strategies are needed for better patient care and survival.
Area of Science:
- Oncology
- Clinical Nutrition
- Gastroenterology
Background:
- Pancreatic cancer (PaC) significantly impacts patient nutritional status.
- Malnutrition risk assessment in PaC is often overlooked, with inconsistent clinical screening tool use.
- Existing research highlights the association between malnutrition and adverse outcomes in PaC patients.
Purpose of the Study:
- To review the assessment of malnutrition risk in pancreatic cancer patients.
- To explore the relationship between malnutrition risk, patient characteristics, and clinical outcomes.
- To identify gaps in current knowledge and clinical practice regarding malnutrition screening in PaC.
Main Methods:
- A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science.
- Searches combined terms related to malnutrition/nutritional risk and screening with pancreatic cancer.
- The review focused on studies assessing malnutrition risk and its clinical implications in PaC.
Main Results:
- Prevalence of malnutrition risk in PaC patients varies widely across studies.
- Higher malnutrition risk is consistently associated with adverse outcomes (e.g., complications, reduced survival).
- Limited comparative studies exist on the reliability and prognostic performance of different screening tools.
Conclusions:
- Optimal approaches for assessing malnutrition risk in PaC patients require further definition.
- Evidence is needed to evaluate the impact of nutritional interventions and integrate screening into care.
- Future research should focus on reliable tools, monitoring risk over time, and identifying optimal cut-off values.
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