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Updated: Mar 28, 2026
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Single-center retrospective cohort study of lung cancer associated with interstitial lung disease: Prognostic factors
A Goga1, G Soussi2, A Mogenet1
1Département de Pneumologie, Hôpital Nord, AP-HM, Marseille, France; Aix Marseille Université, Marseille, France.
Background:
Lung cancer associated with interstitial lung disease (LC-ILD) represents a highly vulnerable population with limited therapeutic options and increased risk of treatment-related complications. Data from Western cohorts remain scarce, especially regarding molecular characteristics and prognostic determinants.
Methods:
We conducted a retrospective single-center cohort study of all consecutive LC-ILD patients discussed in a thoracic oncology multidisciplinary team (MDT) at Marseille University Hospital between June 2010 and July 2025.
Results:
A total of 102 patients were included. Mean age was 68.8 years and 83% were men. UIP was the most frequent ILD pattern (61%). Molecular profiling (available for 57%) showed a landscape dominated by TP53 (38%), KRAS (24% including 9% G12C) and PI3KCA (16%), with no EGFR alterations detected. ARE occurred in 42% of patients and were fatal in 67%. Median OS was 17.7 months. In multivariable analysis, higher KCO (HR 0.97 per 1% increase), good performance status, and curative-intent strategy were independently associated with improved survival.
Conclusion:
KCO and performance status are the strongest independent predictors of survival in LC-ILD. AREs are frequent and highly lethal. Dedicated therapeutic guidelines and an adapted ILD-GAP-cancer prognostic tool are urgently needed. Beyond clinical parameters our findings suggest a distinct molecular landscape dominated by TP53, KRAS and PI3K pathway alteration.
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