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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
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How amphiphilic attributes of cationic dodecapeptides affect their bioactivity against gram-negative pathogens

Ping Zeng1, Chenshuang Zhang2, Lanhua Yi3

  • 1College of Biological and Chemical Engineering, Qilu Institute of Technology, Jinan, China; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

Microbial Pathogenesis
|March 26, 2026
PubMed
Summary

Designing effective antibacterial peptides is challenging. This study identified key physicochemical parameters like GRAVY, Boman index, and SASA within specific ranges that increase the likelihood of antibacterial activity against Gram-negative pathogens.

Keywords:
AmphiphilesAntibacterial peptideCorrelation analysisMinimum inhibitory concentrationPhysical property

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