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Rationalizing Proton Pump Inhibitor Use: Southeast Asia Consensus Recommendations.

Somchai Leelakusolvong1,2, Tju Siang Chua3, Duc Trong Quach4

  • 1Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Journal of Gastroenterology and Hepatology
|March 27, 2026
PubMed
Summary
This summary is machine-generated.

Inappropriate proton pump inhibitor (PPI) use is common in Southeast Asia. This consensus provides recommendations for rationalizing PPI prescribing and deprescribing to improve patient outcomes.

Keywords:
Southeast Asiadeprescriptiondrug prescriptionshealth personnelproton pump inhibitors

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Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Proton pump inhibitors (PPIs) are widely used for gastrointestinal conditions.
  • Inappropriate prescription of PPIs is a significant concern in Southeast Asia (SEA).
  • Lack of region-specific guidelines necessitates tailored recommendations for PPI use.

Purpose of the Study:

  • To develop recommendations for rationalizing PPI prescribing in SEA.
  • To address the issue of inappropriate long-term PPI use and its potential adverse effects.
  • To guide healthcare providers in SEA on appropriate PPI initiation, review, and deprescribing.

Main Methods:

  • A working group of 14 experts from six SEA countries was formed.
  • Evidence review and a modified Delphi method with anonymous voting were employed.
  • Twenty consensus statements were developed covering PPI overprescription, rationalization benefits/barriers, criteria, and strategies.

Main Results:

  • Widespread inappropriate long-term PPI prescription in SEA was confirmed, posing risks.
  • While PPI rationalization offers benefits, implementation challenges exist.
  • Specific indications for PPI initiation, regular review for deprescribing, and strategies like shared decision-making and rescue therapy were outlined.

Conclusions:

  • The consensus document aims to enhance PPI prescribing and deprescribing practices in SEA.
  • Recommendations focus on rationalization strategies to optimize PPI use.
  • Improved PPI management is expected to benefit patients across the region.