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High-channel-count neural recording and stimulation platform with 5,376 simultaneous recording channels
Yingying Fan1,2, Yuhang Ma3,2, Pavlo Zolotavin1,4
1Department of Electrical and Computer Engineering, Houston, TX, USA.
Biorxiv : the Preprint Server for Biology
|March 27, 2026
Summary
Researchers developed a scalable neural interface integrating electrodes with custom application-specific integrated circuits (ASICs). This high-density system enables precise, full-spectrum neural recording for advanced brain-computer interfaces and neuroprosthetics.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Electrical Engineering
Background:
- Advancing neural interfaces demands large-scale, high-density recording technologies for comprehensive neural activity capture.
- Current technologies face limitations in scalability and integration for full-spectrum brain region analysis.
Purpose of the Study:
- To present a scalable approach for integrating neural electrodes with advanced application-specific integrated circuits (ASICs).
- To develop a high-density neural recording platform for precise in vivo brain activity mapping.
Main Methods:
- Custom-designed an ASIC with 5,376 simultaneous channels, sampling at 20 kS/s with >1.3 Gb/s data throughput.
- Incorporated in-pixel amplification, time-division multiplexed ADCs, and on-chip stimulation for precise signal acquisition.
- Utilized gold bump bonding for high-density integration of flexible probes and rigid chips.
Main Results:
- Achieved a low noise level of 5.5 µVrms with minimal power consumption.
- Demonstrated high-resolution in vivo field potential mapping on rat cortical surfaces.
- Successfully localized evoked sensory activities with the integrated platform.
Conclusions:
- The developed platform offers an effective approach for highly integrated neural interfaces.
- This technology has significant applications in brain-computer interfaces, neuroprosthetics, and large-scale functional brain mapping.
