Association between psoriasis and oral pemphigus vulgaris: Report of two cases

The aim of this study is to illustrate the coexistence of these autoimmune conditions in the same patient, through the presentation of two case reports. Clinical Case 1: Male patient, fair-skinned, 43 years old, presenting with ulcerated and disseminated oral lesions for approximately six months, along with scaly lesions on the neck and elbows, previously diagnosed as psoriasis. An oral biopsy confirmed a diagnosis consistent with pemphigus vulgaris. Clinical Case 2: A 51-year-old fair-skinned male reported pain in the inner region of the mouth and throat for the past four months, associated with widespread ulcerative lesions. In addition, he presented scaly areas on the scalp. The findings confirmed a concomitant diagnosis of pemphigus vulgaris and psoriasis. In all cases, systemic corticosteroid therapy was prescribed, and the patients remain under joint follow-up care in the of Stomatology and Dermatology. Therefore, a thorough investigation through clinical, laboratory, and histopathological examinations is indispensable for the proper management of these conditions, ensuring effective treatment.